WO2002101019A3 - Methods of culturing animal cells and polypeptide production in animal cells - Google Patents
Methods of culturing animal cells and polypeptide production in animal cells Download PDFInfo
- Publication number
- WO2002101019A3 WO2002101019A3 PCT/US2002/018687 US0218687W WO02101019A3 WO 2002101019 A3 WO2002101019 A3 WO 2002101019A3 US 0218687 W US0218687 W US 0218687W WO 02101019 A3 WO02101019 A3 WO 02101019A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- methods
- animal cells
- polypeptides
- cell culture
- culturing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/32—Amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/34—Sugars
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
Abstract
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP02746513A EP1404813A4 (en) | 2001-06-13 | 2002-06-11 | Methods of culturing animal cells and polypeptide production in animal cells |
CA002447791A CA2447791A1 (en) | 2001-06-13 | 2002-06-11 | Methods of culturing animal cells and polypeptide production in animal cells |
AU2002316230A AU2002316230A1 (en) | 2001-06-13 | 2002-06-11 | Methods of culturing animal cells and polypeptide production in animal cells |
JP2003503770A JP2004532642A (en) | 2001-06-13 | 2002-06-11 | Animal cell culture method and polypeptide production in animal cells |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US29801301P | 2001-06-13 | 2001-06-13 | |
US60/298,013 | 2001-06-13 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2002101019A2 WO2002101019A2 (en) | 2002-12-19 |
WO2002101019A3 true WO2002101019A3 (en) | 2003-04-10 |
Family
ID=23148629
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2002/018687 WO2002101019A2 (en) | 2001-06-13 | 2002-06-11 | Methods of culturing animal cells and polypeptide production in animal cells |
Country Status (6)
Country | Link |
---|---|
US (1) | US20030087372A1 (en) |
EP (1) | EP1404813A4 (en) |
JP (1) | JP2004532642A (en) |
AU (1) | AU2002316230A1 (en) |
CA (1) | CA2447791A1 (en) |
WO (1) | WO2002101019A2 (en) |
Families Citing this family (64)
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---|---|---|---|---|
US20030109680A1 (en) * | 2001-11-21 | 2003-06-12 | Sunol Molecular Corporation | Antibodies for inhibiting blood coagulation and methods of use thereof |
US5986065A (en) * | 1997-03-10 | 1999-11-16 | Sunol Molecular Corporation | Antibodies for inhibiting blood coagulation and methods of use thereof |
US7749498B2 (en) * | 1997-03-10 | 2010-07-06 | Genentech, Inc. | Antibodies for inhibiting blood coagulation and methods of use thereof |
US20060235209A9 (en) * | 1997-03-10 | 2006-10-19 | Jin-An Jiao | Use of anti-tissue factor antibodies for treating thromboses |
WO2002066603A2 (en) | 2001-02-15 | 2002-08-29 | Centocor, Inc. | Chemically defined medium for cultured mammalian cells |
WO2004099396A1 (en) * | 2003-05-09 | 2004-11-18 | Crucell Holland B.V. | Cultures of e1-immortalized cells and processes for culturing the same to increase product yields therefrom |
ES2344789T5 (en) * | 2003-05-15 | 2017-06-14 | Wyeth Llc | Restricted glucose feeding for animal cell culture |
ES2527102T3 (en) * | 2003-06-19 | 2015-01-20 | Genentech, Inc. | Compositions and methods for the treatment of disorders related to coagulation |
JP4740138B2 (en) * | 2003-10-10 | 2011-08-03 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | Method for large-scale production of polypeptides in eukaryotic cells and culture vessels suitable therefor |
RU2451082C2 (en) * | 2004-08-27 | 2012-05-20 | Вайет Рисёрч Айрлэнд Лимитед | Production of polypeptides |
TWI374935B (en) | 2004-08-27 | 2012-10-21 | Pfizer Ireland Pharmaceuticals | Production of α-abeta |
US7300773B2 (en) * | 2004-08-27 | 2007-11-27 | Wyeth Research Ireland Limited | Production of TNFR-Ig |
TWI384069B (en) | 2004-08-27 | 2013-02-01 | Pfizer Ireland Pharmaceuticals | Production of polypeptides |
AU2012200353B2 (en) * | 2004-08-27 | 2014-06-19 | Pfizer Ireland Pharmaceuticals | PRODUCTION OF a-ABeta |
PL3121266T3 (en) | 2006-01-04 | 2020-07-13 | Baxalta Incorporated | Oligopeptide-free cell culture media |
AR059065A1 (en) * | 2006-01-23 | 2008-03-12 | Amgen Inc | METHODS TO MODULATE THE MANOSA CONTENT OF THE RECOMBINANT PROTEINS |
KR20140132017A (en) | 2006-09-13 | 2014-11-14 | 애브비 인코포레이티드 | Cell culture improvements |
EP2115126B1 (en) | 2007-03-02 | 2015-04-08 | Wyeth LLC | Use of copper and glutamate in cell culture for production of polypeptides |
JP5456658B2 (en) * | 2007-03-30 | 2014-04-02 | メディミューン,エルエルシー | Antibody preparation |
US20110137012A1 (en) | 2007-04-26 | 2011-06-09 | Chugai Seiyaku Kabushiki Kaisha | Cell culture method using amino acid-enriched medium |
CN112480255A (en) | 2007-07-09 | 2021-03-12 | 健泰科生物技术公司 | Prevention of disulfide bond reduction during recombinant production of polypeptides |
ES2657055T3 (en) | 2007-08-09 | 2018-03-01 | Wyeth Llc | Use of perfusion to improve the production of a batch-fed cell culture in bioreactors |
ES2543061T3 (en) * | 2008-04-17 | 2015-08-14 | Wyeth Llc | Improved production procedures for bone morphogenetic proteins |
WO2010016943A2 (en) * | 2008-08-08 | 2010-02-11 | Biogen Idec Ma Inc. | Nutrient monitoring and feedback control for increased bioproduct production |
PT2464725T (en) | 2009-08-11 | 2020-05-21 | Hoffmann La Roche | Production of proteins in glutamine-free cell culture media |
BR112012009828B8 (en) | 2009-10-26 | 2022-10-25 | Hoffmann La Roche | METHOD FOR THE PRODUCTION OF A GLYCOSYLED IMMUNOGLOBULIN AND ITS USE |
EP3431608A3 (en) | 2009-11-17 | 2019-02-20 | E. R. Squibb & Sons, L.L.C. | Method for enhanced protein production |
US20130210075A1 (en) * | 2010-01-07 | 2013-08-15 | Dr. Reddy's Laboratories, Inc. | Enhanced protein expression |
WO2011134919A2 (en) | 2010-04-26 | 2011-11-03 | Novartis Ag | Improved cell cultivation process |
RU2563353C2 (en) | 2010-04-26 | 2015-09-20 | Новартис Аг | Improved cell culture medium |
AU2011246503B2 (en) | 2010-04-26 | 2013-09-26 | Novartis Ag | Improved cell culture medium |
PT2616090T (en) * | 2010-09-17 | 2023-10-16 | Takeda Pharmaceuticals Co | Stabilization of immunoglobulins through aqueous formulation with histidine at weak acidic to neutral ph |
WO2012149197A2 (en) | 2011-04-27 | 2012-11-01 | Abbott Laboratories | Methods for controlling the galactosylation profile of recombinantly-expressed proteins |
US9670519B2 (en) * | 2011-04-29 | 2017-06-06 | Biocon Limited | Methods for reducing accumulation of lactate during culturing and method for producing polypeptide |
MY169935A (en) * | 2011-04-29 | 2019-06-18 | Biocon Biologics India Ltd | "a method for reducing heterogeneity of antibodies and a process of producing the antibodies thereof" |
EP2837680B1 (en) | 2011-07-01 | 2020-02-26 | Amgen Inc. | Mammalian cell culture |
WO2013158279A1 (en) | 2012-04-20 | 2013-10-24 | Abbvie Inc. | Protein purification methods to reduce acidic species |
US9181572B2 (en) | 2012-04-20 | 2015-11-10 | Abbvie, Inc. | Methods to modulate lysine variant distribution |
US9067990B2 (en) | 2013-03-14 | 2015-06-30 | Abbvie, Inc. | Protein purification using displacement chromatography |
RU2496869C1 (en) * | 2012-04-23 | 2013-10-27 | Государственное научное учреждение Прикаспийский зональный научно-исследовательский ветеринарный институт Российской академии сельскохозяйственных наук | Method to cultivate human and animal cells |
US20130281355A1 (en) | 2012-04-24 | 2013-10-24 | Genentech, Inc. | Cell culture compositions and methods for polypeptide production |
US9512214B2 (en) | 2012-09-02 | 2016-12-06 | Abbvie, Inc. | Methods to control protein heterogeneity |
EP2830651A4 (en) | 2013-03-12 | 2015-09-02 | Abbvie Inc | Human antibodies that bind human tnf-alpha and methods of preparing the same |
US9499614B2 (en) | 2013-03-14 | 2016-11-22 | Abbvie Inc. | Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosaccharides |
US9017687B1 (en) | 2013-10-18 | 2015-04-28 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same using displacement chromatography |
US9217168B2 (en) | 2013-03-14 | 2015-12-22 | Momenta Pharmaceuticals, Inc. | Methods of cell culture |
ES2798307T3 (en) | 2013-03-15 | 2020-12-10 | Hoffmann La Roche | Antioxidant Cell Culture Compositions and Procedures for Polypeptide Production |
CA2913687C (en) | 2013-07-04 | 2022-12-13 | F. Hoffmann-La Roche Ag | Interference-suppressed immunoassay to detect anti-drug antibodies in serum samples |
EP3052640A2 (en) | 2013-10-04 | 2016-08-10 | AbbVie Inc. | Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins |
US11390663B2 (en) | 2013-10-11 | 2022-07-19 | Regeneron Pharmaceuticals, Inc. | Metabolically optimized cell culture |
US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
US9181337B2 (en) | 2013-10-18 | 2015-11-10 | Abbvie, Inc. | Modulated lysine variant species compositions and methods for producing and using the same |
WO2015073884A2 (en) | 2013-11-15 | 2015-05-21 | Abbvie, Inc. | Glycoengineered binding protein compositions |
US20170166941A1 (en) * | 2014-01-29 | 2017-06-15 | Lg Life Sciences Ltd. | Method for modulating galactosylation of recombinant protein through optimization of culture medium |
WO2015128795A1 (en) * | 2014-02-25 | 2015-09-03 | Dr. Reddy's Laboratories Limited | Process for modifying galactosylation and g0f content of a glycoprotein composition by glutamine supplementation |
MA40864A (en) | 2014-10-31 | 2017-09-05 | Biogen Ma Inc | HYPOTAURINE, GABA, BETA-ALANINE AND CHOLINE FOR THE REGULATION OF THE ACCUMULATION OF RESIDUAL BY-PRODUCTS IN MAMMAL CELL CULTURE PROCESSES |
TW202340452A (en) | 2015-08-04 | 2023-10-16 | 美商再生元醫藥公司 | Taurine supplemented cell culture medium and methods of use |
JP2020005511A (en) * | 2018-07-03 | 2020-01-16 | 株式会社日立製作所 | Culture method and culture apparatus |
US20220204920A1 (en) * | 2019-05-16 | 2022-06-30 | Formycon Ag | Method for reducing methionine oxidation in recombinant proteins |
CN110257319A (en) * | 2019-07-26 | 2019-09-20 | 苏州瑞徕生物科技有限公司 | A kind of cells on microcarriers maintains the culture solution and method of culture |
IL296893B1 (en) | 2019-12-06 | 2024-01-01 | Regeneron Pharma | Anti-vegf protein compositions and methods for producing the same |
US20230323422A1 (en) * | 2020-08-14 | 2023-10-12 | Bristol-Myers Squibb Company | Method of making protein |
CA3215302A1 (en) * | 2021-04-14 | 2022-10-20 | Shawn L. BARRETT | Methods of perfusion culturing a mammalian cell |
AU2022263986A1 (en) * | 2021-04-27 | 2023-11-09 | Amgen Inc. | Modulating product quality of asymmetric multispecific antibodies through the use of temperature |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5672502A (en) * | 1985-06-28 | 1997-09-30 | Celltech Therapeutics Limited | Animal cell culture |
US5721121A (en) * | 1995-06-06 | 1998-02-24 | Genentech, Inc. | Mammalian cell culture process for producing a tumor necrosis factor receptor immunoglobulin chimeric protein |
US6156570A (en) * | 1997-03-20 | 2000-12-05 | Regents Of The University Of Minnesota | Process for the continuous culture of cells |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US30985A (en) * | 1860-12-18 | Thomas l | ||
US3926723A (en) * | 1974-08-08 | 1975-12-16 | Massachusetts Inst Technology | Method of controllably releasing glucose to a cell culture medium |
US4560655A (en) * | 1982-12-16 | 1985-12-24 | Immunex Corporation | Serum-free cell culture medium and process for making same |
US4657866A (en) * | 1982-12-21 | 1987-04-14 | Sudhir Kumar | Serum-free, synthetic, completely chemically defined tissue culture media |
US4767704A (en) * | 1983-10-07 | 1988-08-30 | Columbia University In The City Of New York | Protein-free culture medium |
US4724206A (en) * | 1984-02-13 | 1988-02-09 | Damon Biotech, Inc. | Protein production using hypertonic media |
US4927762A (en) * | 1986-04-01 | 1990-05-22 | Cell Enterprises, Inc. | Cell culture medium with antioxidant |
US6238891B1 (en) * | 1987-11-18 | 2001-05-29 | Cetus Oncology Corporation | Method of increasing product expression through solute stress |
US5151359A (en) * | 1988-05-19 | 1992-09-29 | Mitsui Toatsu Chemicals Incorporated | Method for producing of human tissue type plasminogen activator |
US5122469A (en) * | 1990-10-03 | 1992-06-16 | Genentech, Inc. | Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins |
US6180403B1 (en) * | 1999-10-28 | 2001-01-30 | Isis Pharmaceuticals Inc. | Antisense inhibition of tumor necrosis factor alpha converting enzyme (TACE) expression |
US5736137A (en) * | 1992-11-13 | 1998-04-07 | Idec Pharmaceuticals Corporation | Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma |
US5856179A (en) * | 1994-03-10 | 1999-01-05 | Genentech, Inc. | Polypeptide production in animal cell culture |
US5705364A (en) * | 1995-06-06 | 1998-01-06 | Genentech, Inc. | Mammalian cell culture process |
JP4306813B2 (en) * | 1995-09-19 | 2009-08-05 | アスビオファーマ株式会社 | New method for culturing animal cells |
US6087129A (en) * | 1996-01-19 | 2000-07-11 | Betagene, Inc. | Recombinant expression of proteins from secretory cell lines |
US6237791B1 (en) * | 1997-04-09 | 2001-05-29 | Dtl Technology Limited Partnership | Wide mouth hot fill container |
US6171586B1 (en) * | 1997-06-13 | 2001-01-09 | Genentech, Inc. | Antibody formulation |
US6172213B1 (en) * | 1997-07-02 | 2001-01-09 | Genentech, Inc. | Anti-IgE antibodies and method of improving polypeptides |
US5994511A (en) * | 1997-07-02 | 1999-11-30 | Genentech, Inc. | Anti-IgE antibodies and methods of improving polypeptides |
-
2002
- 2002-06-11 WO PCT/US2002/018687 patent/WO2002101019A2/en active Application Filing
- 2002-06-11 AU AU2002316230A patent/AU2002316230A1/en not_active Abandoned
- 2002-06-11 US US10/167,517 patent/US20030087372A1/en not_active Abandoned
- 2002-06-11 JP JP2003503770A patent/JP2004532642A/en active Pending
- 2002-06-11 CA CA002447791A patent/CA2447791A1/en not_active Abandoned
- 2002-06-11 EP EP02746513A patent/EP1404813A4/en not_active Withdrawn
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5672502A (en) * | 1985-06-28 | 1997-09-30 | Celltech Therapeutics Limited | Animal cell culture |
US5721121A (en) * | 1995-06-06 | 1998-02-24 | Genentech, Inc. | Mammalian cell culture process for producing a tumor necrosis factor receptor immunoglobulin chimeric protein |
US6156570A (en) * | 1997-03-20 | 2000-12-05 | Regents Of The University Of Minnesota | Process for the continuous culture of cells |
Also Published As
Publication number | Publication date |
---|---|
US20030087372A1 (en) | 2003-05-08 |
AU2002316230A1 (en) | 2002-12-23 |
CA2447791A1 (en) | 2002-12-19 |
EP1404813A2 (en) | 2004-04-07 |
JP2004532642A (en) | 2004-10-28 |
EP1404813A4 (en) | 2004-11-24 |
WO2002101019A2 (en) | 2002-12-19 |
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